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Dapagliflozin

Last updated on 08/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Dapagliflozin

CHINESE NAME: 達格列淨

BRAND NAME(S) IN HONG KONG: Forxiga 糖適雅

DRUG CLASS: Antidiabetic drugs

SUB CLASS: SGLT-2 inhibitors

USED FOR: Type 2 diabetes, Heart failure with reduced ejection fraction, Chronic kidney disease

AVAILABLE DOSAGE FORMS:
– 5mg, 10mg (tablets)

What is Dapagliflozin for?

Dapagliflozin belongs to a class of medications called SGLT-2 inhibitors. It works by preventing reabsorption of sugar and facilitating its excretion in urine to control blood sugar level. On the other hand, Dapagliflozin can reduce sodium reabsorption which influences several physiological functions. 

It is indicated for the treatment of type 2 diabetes mellitus and reduction of risk of hospitalization for cardiovascular disease in diabetic patients. Also, it can be used to treat heart failure independently of diabetes. 

Most recently in April 2021, Dapagliflozin has been approved for the treatment of chronic kidney disease (CKD). It can improve the function of the kidney and reduce the risk of cardiovascular disease in CKD patients who are at risk of disease progression.

How to use it?

Dapagliflozin is administered orally as tablets.

For type 2 diabetes:
The usual initial dose is 5 mg once daily in the morning. You may increase the dose to 10 mg once daily after 4-12 weeks if needed to achieve glycemic goals.

For reduction of risk of hospitalization for heart failure in type 2 diabetic patients:
The usual dose is 10 mg once daily.

For heart failure with reduced ejection fraction independently of diabetes:
The usual dose is 10 mg once daily.

For chronic kidney disease:
The usual dose is 10 mg once daily.

What are the side effects of Dapagliflozin?

Common side effects of Dapagliflozin include increased urination, back pain, nasopharyngitis, urinary tract infection, or vaginal yeast infection.

Who should not take Dapagliflozin?

– People who are allergic to Dapagliflozin or any component of the formulation
– Patients with severe renal impairment, or on dialysis.

Pharmacist Tips:

– Non-drug management, including diet and exercise, also plays an important role in controlling both diabetes.
– Seek medical advice promptly if your body is under stress such as fever, trauma, infection, or surgery, as medication requirements may change.
– Since urinary tract infection or genital yeast infection is a common adverse effect using Empagliflozin, report any signs or symptoms of burning sensation when peeing or redness.
– Report any signs or symptoms of hypotension promptly such as lightheadedness, blurred vision.

Common dosing schedule:
Dapagliflozin can be taken with or without food.

For blood sugar control, Dapagliflozin should be taken in the morning.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Dapagliflozin may interact with:
– Rifampicin
– Insulin
– Sulfonylureas, e.g. Glipizide, Gliclazide

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Dapagliflozin in Hong Kong?

In Hong Kong, Dapagliflozin is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Dapagliflozin in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.