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Danazol

Last updated on 15/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Danazol

CHINESE NAME: 達那唑

BRAND NAME(S) IN HONG KONG: Danocrine, Azol-100, Anargil, Ectopal

DRUG CLASS: Endocrine Drugs

SUB CLASS: Androgens

USED FOR: Endometriosis, Hereditary angioedema

AVAILABLE DOSAGE FORMS:
– 100 mg, 200 mg (capsules)

What is Danazol for?

Danazol belongs to the class of endocrine drugs. It is an androgen resembling male sex hormones to inhibit female sex hormones so as to treat endometriosis and hereditary angioedema.

How to use it?

Danazol is taken orally as capsules. Taking on either an empty stomach or after meals is acceptable, but the timing has to be consistent throughout the regimen.

Mild endometriosis
Adult
200-400 mg daily in 2 divided doses initially. Reduce dose gradually to maintain the absence of menstruation. Danazol should be used continuously for 3-9 months.

Moderate to severe endometriosis
Adult
800 mg daily in 2 divided doses initially. Reduce dose gradually to maintain the absence of menstruation. Danazol should be used continuously for 3-9 months.

Long-term prevention of hereditary angioedema
Adult
100-200 mg once daily. Reduce dose gradually depending on the frequency of attack.
Child ≥16 years of age
Initially 2.5 mg/kg daily at a maximum dose of 50 mg daily. Increase the dose slowly biweekly to a maximum dose of 5 mg/kg daily or 200 mg daily depending on which one is smaller. Reduce dose gradually depending on the control of the angioedema.

What are the side effects of Danazol?

Common side effects of Danazol include acne, decrease in breast size, weight gain, oily skin and flushing.

Who should not take Danazol?

– People who are allergic to Danazol or any component of the formulation
– Patients with undiagnosed abnormal genital bleeding, porphyria or androgen-dependent tumor
– Pregnant women or those who are breastfeeding
– People on simvastatin
– People who are markedly renally, hepatically, cardiacally impaired or has history of thrombotic events

Pharmacist Tips:

– Administer Danazol same time each day with the meal arrangement, always take with meals or on an empty stomach
– Initiate therapy during menstruation

Common dosing schedule:
Depending on the indication, Danazol can be taken once to twice daily. 

For those taking once daily, Danazol can be taken at around breakfast.

For those taking twice daily, Danazol can be taken at around breakfast and dinner.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Danazol may interact with:
– CYP3A4 substrates, e.g. Alprazolam, Nimodipine, Sirolimus
– Vitamin D analogs, e.g. Alfacalcidol, Calcitriol
– Vitamin K antagonists, e.g. Warfarin
Cyclosporin
– Antidiabetic agents, e.g. Metformin, Glipizide, Insulin

Danazol may interact with many other medications. Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Danazol in Hong Kong?

In Hong Kong, Danazol is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Danazol in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.