Medicines & Supplements A to Z > Clomipramine

Clomipramine

Last updated on 08/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions   |   Tips   |   Where To Buy  

GENERIC NAME: Clomipramine

CHINESE NAME: 氯米帕明

BRAND NAME(S) IN HONG KONG: Anafranil 安納福寧

DRUG CLASS: Antidepressants

SUB CLASS: Tricyclic antidepressants

USED FOR: Obsessive-compulsive disorder

AVAILABLE DOSAGE FORMS:
– 10mg, 25mg (tablets)

What is Clomipramine for?

Clomipramine belongs to a class of medications called tricyclic antidepressants. It is used to treat obsessive-compulsive disorder, which is a mental disorder in which a person has uncontrollable, recurring thoughts and/or repeatable behaviors.

How to use it?

Clomipramine can be taken orally as tablets. 

For obsessive-compulsive disorder:
Initial dose: 25 mg once daily, dose to be increased gradually over the first 2 weeks.
Maintenance dose: 100 mg/day
Maximum daily dose: 250mg

What are the side effects of Clomipramine?

Common side effects of Clomipramine include dry mouth, constipation, sweating, nausea, decreased sex drive, weight gain, or male sexual dysfunction.

Who should not take Clomipramine?

– People who are allergic to Clomipramine, any component of the formulation, or other tricyclic antidepressants, such as Imipramine, Nortriptyline
– Patients during the acute recovery period after a myocardial infarction
– Patients taking monoamine oxidase inhibitors, such as Selegiline, Rasagiline

Pharmacist Tips:

Patients should avoid abrupt discontinuation of the drug to prevent withdrawal symptoms.

Common dosing schedule:
Clomipramine should be taken with food to minimize gastrointestinal disturbance. 

Divide the total daily dose during titration phases for administration. After that, Clomipramine may be given as a single once daily dose at bedtime.

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Clomipramine may interact with:
– Cimetidine
– Blood pressure lowering agents
– Serotonergic agents, e.g. Tramadol, Buspirone, Fentanyl
– Antidepressants, e.g. Fluoxetine, Paroxetine

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Clomipramine in Hong Kong?

In Hong Kong, Clomipramine is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Clomipramine in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.