Clexane

Used for: Prophylaxis of venous thromboembolism (VTE), Unstable angina, Treatment of venous thromboembolism (VTE), Acute myocardial infarction, Ischemic heart disease
Chinese name:

What is Clexane for?

Clexane is a brand medication that contains Enoxaparin, which belongs to a class of medications called low molecular weight heparin. It works by inhibiting the blood clotting process to reduce blood clot formation in your body. It is used for unstable angina, myocardial infarction, prevention and treatment of venous thromboembolism (e.g. Deep vein thrombosis (DVT)).

How to use it?

Clexane is available as injections. It is administered by subcutaneous injection for most conditions, but also by intravenous injection. For renal impaired patients, children and elderly may need a lower dose.
 

For unstable angina, non-ST segment elevation myocardial infarction (non-STEMI):
1 mg/kg subcutaneously every 12 hours for 2-8 days, with oral Aspirin 100-325 mg

 

For acute ST segment elevation myocardial infarction (STEMI):
30 mg single intravenous bolus plus a 1 mg/kg subcutaneous dose followed by 1 mg/kg subcutaneously every 12 hours for at least 8 days, with oral Aspirin 75-325 mg.

 

For prophylaxis of DVT in knee or hip replacement surgeries:
30 mg subcutaneously every 12 hours up to 14 days OR 40 mg subcutaneously once daily up to 14 days. The usual duration of administration is 7-10 days.

 

For prophylaxis of DVT in abdominal surgery:
40 mg subcutaneously once daily up to 12 days. The usual duration of administration is 7-10 days.

 

For prophylaxis of DVT in medical patients during acute illness:
40 mg subcutaneously once daily up to 14 days. The usual duration of administration is 6-11 days.

 

For outpatient treatment of acute DVT without pulmonary embolism:
1 mg/kg subcutaneously every 12 hours up to 17 days. Initiate warfarin sodium when appropriate (usually within 72 hours of Enoxaparin), then continue Enoxaparin for at least 5 days and until a therapeutic anticoagulant effect is achieved (INR 2-3).

 

For inpatient treatment of acute DVT with or without pulmonary embolism:
1 mg/kg subcutaneously every 12 hours up to 17 days. Initiate warfarin sodium when appropriate (usually within 72 hours of Enoxaparin), then continue Enoxaparin for at least 5 days and until a therapeutic anticoagulant effect is achieved (INR 2-3).

What are the side effects of Clexane?

Common side effects of Clexane include oedema, diarrhoea, nausea and fever.

Who should not take Clexane?

  • Anyone who is allergic to any component of Clexane and benzyl alcohol.
  • Patients with active major bleeding
  • History of heparin-induced thrombocytopenia (HIT)

Pharmacist Tips:

  • For you are self-administering, you will be instructed how to inject.
  • The injection site should be on the left or right side of the abdominal wall, which is approximately 3 inches from the belly button.
  • It is important to change your injection sites every time you inject.
  • Enoxaparin may increase the risk of bleeding. If unusual/excessive bleeding occurs, report to your doctor immediately.

Common dosing schedule:
N/A

 

This schedule is for reference only, adjustments may be made according to individual needs.

 

Some common medications Clexane may interact with:

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Clexane in Hong Kong?

In Hong Kong, Clexane is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

 

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Clexane in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.

Available dosage
  • 20mg/0.2ml / 40mg/0.4ml (Injections)
Drug class
Anticoagulants
Sub class
Heparins (Low-Molecular-Weight Heparin, LMWH)
Generic Names
Other drugs in same class
Enoxaparin
Used for: Treatment of venous thromboembolism (VTE), Acute myocardial infarction, Prophylaxis of venous thromboembolism (VTE), Ischemic heart disease, Unstable angina
Chinese name: