Amphotericin B is a type of polyene antifungals. It is used to treat leishmaniasis and life-threatening fungal infections, such as aspergillosis, candidiasis, histoplasmosis, and sporotrichosis.
Amphotericin B is administered via intravenous injection. Listed below are the indications and the dosages.
0.6-0.7 mg/kg/day for 3-6 months.
0.7-1 mg/kg/day for 1-2 weeks, followed by oral itraconazole for 6-12 months.
Candidiasis of the esophagus:
0.3-0.7 mg/kg/day IV for 14-21 days.
Candidiasis of the esophagus with HIV infection:
0.6 mg/kg/day IV for 14-21 days.
Coccidioidomycosis disease in patients with HIV:
0.7-1 mg/kg/day until clinical improvement, then switch to either Fluconazole or Itraconazole.
Cryptococcal disease in patients with HIV:
0.7-1 mg/kg/day (with/without Fluconazole) for 2 weeks, followed by oral Fluconazole for maintenance therapy.
0.7-1 mg/kg/day for 1-2 weeks, followed by Itraconazole
0.5-1 mg/kg/day once daily or every other day for a total cumulative dose of ~15-30 mg/kg.
0.5-1 mg/kg/day once daily or every other day for a total cumulative dose of ~20-45 mg/kg.
In Hong Kong, Amphotericin B is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.
For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk
Need more information?
For detailed information about the use of Amphotericin B in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.
Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.
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