Medicines & Supplements A to Z > Amphotericin B

Amphotericin B

Last updated on 09/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Amphotericin B

ALTERNATIVE NAME: Amphotericin B deoxycholate

CHINESE NAME: 兩性黴素B

BRAND NAME(S) IN HONG KONG: Fungizone 防治黴

DRUG CLASS: Antifungals

SUB CLASS: Polyenes

USED FOR: Fungal infections, Leishmaniasis

AVAILABLE DOSAGE FORMS:
– 50mg (injections)

What is Amphotericin B for?

Amphotericin B is a type of polyene antifungals. It is used to treat leishmaniasis and life-threatening fungal infections, such as aspergillosis, candidiasis, histoplasmosis, and sporotrichosis.

How to use it?

Amphotericin B is administered via intravenous injection. Listed below are the indications and the dosages. 

Disseminated aspergillosis:
0.6-0.7 mg/kg/day for 3-6 months.

Blastomycosis:
0.7-1 mg/kg/day for 1-2 weeks, followed by oral itraconazole for 6-12 months.

Candidiasis of the esophagus:
0.3-0.7 mg/kg/day IV for 14-21 days.

Candidiasis of the esophagus with HIV infection:
0.6 mg/kg/day IV for 14-21 days.

Invasive candidiasis:
0.5-0.7 mg/kg/day.

Coccidioidomycosis disease in patients with HIV:
0.7-1 mg/kg/day until clinical improvement, then switch to either Fluconazole or Itraconazole.

Cryptococcal disease in patients with HIV:
0.7-1 mg/kg/day (with/without Fluconazole) for 2 weeks, followed by oral Fluconazole for maintenance therapy.

Histoplasmosis:
0.7-1 mg/kg/day for 1-2 weeks, followed by Itraconazole

Cutaneous leishmaniasis:
0.5-1 mg/kg/day once daily or every other day for a total cumulative dose of ~15-30 mg/kg/

Mucosal leishmaniasis:
0.5-1 mg/kg/day once daily or every other day for a total cumulative dose of ~20-45 mg/kg.

What are the side effects of Amphotericin B?

Common side effects of Amphotericin B include headache, stomach pain, nausea, vomiting, diarrhea, malaise, and decreased appetite.

Who should not take Amphotericin B?

People who are allergic to Amphotericin B or any component of the formulation.

Pharmacist Tips:

Common dosing schedule:
N/A. 

This schedule is for reference only, adjustments may be made according to individual needs.

Some common medications Amphotericin B may interact with:
– Corticosteroids, e.g. Prednisolone, Prednisone
– Antifungals, e.g. Ketoconazole, Clotrimazole
Digoxin

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Amphotericin B in Hong Kong?

In Hong Kong, Amphotericin B is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Amphotericin B in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.