> Western Medicines > Agomelatine


Chinese name:

What is Agomelatine for?

Agomelatine belongs to a class of medication called melatonin receptor agonists. It increases the level of certain neurotransmitters (i.e. norepinephrine and dopamine) in the brain. Therefore, it is indicated for the treatment of major depression.

How to use it?

Agomelatine is taken by mouth as tablets. The usual dose is 25 mg once daily at bedtime. If symptoms do not improve after 2 weeks, you may increase the dose to 50 mg once daily at bedtime, which is the maximum dose. The duration of treatment should be at least 6 months to ensure that you are free of symptoms.

What are the side effects of Agomelatine?

Common side effects of Agomelatine include headache, insomnia, nausea, vomiting, diarrhoea, constipation, abdominal pain, back pain, tiredness, and anxiety.

Who should not take Agomelatine?

  • People who are allergic to Agomelatine or any component of the formulation
  • Patients with liver problems
  • Patients taking Fluvoxamine or Ciprofloxacin

Pharmacist Tips:

  • This medication may cause damage to your liver, so your doctor may require you to run laboratory tests to check that your liver is working properly before starting treatment and then periodically during treatment. You should report any signs or symptoms of liver injury immediately, such as dark urine, light-coloured stools, yellow skins or eyes, or pain in the upper right belly.
  • Smoking or drinking alcohol is not advisable during treatment.

Common dosing schedule:
Agomelatine can be taken with or without food. It should be taken at bedtime for better efficacy.


This schedule is for reference only, adjustments may be made according to individual needs.


Some common medications Agomelatine may interact with:

Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Agomelatine in Hong Kong?

In Hong Kong, Agomelatine is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.


For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Agomelatine in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.

Brands in Hong Kong
Available dosage
  • 25mg (Tablets)
Drug class
Sub class
Melatonin Receptor Agonists
Other drugs in same class