Medicines & Supplements A to Z > Abiraterone

Abiraterone

Last updated on 14/07/2021.

Overview   |   Dosage   |    Side Effects   |   Precautions  |   Tips  |   Where To Buy  

GENERIC NAME: Abiraterone

CHINESE NAME: 阿比特龍

BRAND NAME(S) IN HONG KONG: Zytiga 澤珂

DRUG CLASS: Antineoplastics

SUB CLASS: Androgen antagonists

USED FOR: Treatment of prostate cancer, Cancer hormone therapy

AVAILABLE DOSAGE FORMS:
– 250 mg, 500 mg (tablets)

What is Abiraterone for?

Abiraterone is an antineoplastic that inhibits the synthesis of androgen by inhibiting an enzyme CYP17 selectively and irreversibly. Therefore, it can be used in the treatment of androgen-dependent cancer including prostate cancer.

How to use it?

Abiraterone is administered as tablets orally while receiving a gonadotropin-releasing hormone analog. It should be taken on an empty stomach, at least 1 hour before and 2 hours after food.

Metastatic, castration-resistant prostate cancer
Adult and elderly
1000 mg once daily together with prednisone 5 mg twice daily.

Metastatic, castration-sensitive prostate cancer
Adult and elderly
1000 mg once daily together with prednisone 5 mg twice daily.

What are the side effects of Abiraterone?

Common side effects of Abiraterone include, but not limited to, edema, hypertension, hot flash, hyperglycemia, constipation, bruise, lymphocytopenia, fatigue and muscle pain.

Who should not take Abiraterone?

– People allergic to Abiraterone or any component of the formulation.
– Pregnant women or those who may soon to be pregnant

Pharmacist Tips:

– It should be taken on an empty stomach, at least 1 hour before and 2 hours after food.
– You should be receiving a gonadotropin-releasing hormone analog.
– Do not interchange the Abiraterone formulations, even though there is only Zytiga in Hong Kong.

Common dosing schedule:
Abiraterone tablets are to be taken once daily, preferably in the morning to prevent the effect of insomnia.

This schedule is for reference only, adjustments may be made according to individual needs. 

Some common medications Abiraterone may interact with:
– CYP3A4 inducers, e.g. Diltiazem, Itraconazole, Ritonavir
– CYP2D6 substrates, e.g. Dextromethorphan, Doxorubicin, Clozapine
– Rifabutin
– Rifapentine
Spironolactone

Abiraterone may interact with many other medications. Please notify your doctor or pharmacist if you are taking the above medication, dosage adjustments might be needed.

Where to buy Abiraterone in Hong Kong?

In Hong Kong, Abiraterone is a prescription only medicine, and requires a prescription from a doctor to be purchased in a pharmacy. It can also be obtained from doctors. To find a pharmacy near you, refer to the list of pharmacies (“Authorized Sellers of Poisons”) from the Hong Kong Department of Health.

For more information about drug names and ingredients, you can visit Hong Kong’s Drug Office at https://www.drugoffice.gov.hk

Need more information?

For detailed information about the use of Abiraterone in children, pregnancy and breastfeeding, and for questions about drug interactions, please check with your pharmacist or doctor.

Disclaimer: our goal is to provide you with the most relevant drug information and common dosage for Hong Kong. This information does not constitute medical advice. For specific treatment recommendations and advice, always discuss with your doctor or pharmacist, and follow the instructions included with your specific medicine.